T Cell Engager
“Engineer the Synapse. Elevate the Response.”
Trispecific TCEs designed for precision engagement and deeper activation.
Trispecific T Cell Engager with Signal 2: Built for Precision Immunity
Triple Binding. Single Purpose.
Tumor selectivity, co-stimulation, and immune activation in one. Conventional bispecific T cell engagers (TCEs) often struggle to balance efficacy and safety, particularly in solid tumors. Cyron's Trispecific TCE platform introduces a next-generation concept: a third binding domain that delivers Signal 2—a critical co-stimulatory cue for T cell proliferation.
By incorporating tumor-targeting, CD3 engagement, and a co-stimulatory module (e.g., CD2, our trispecific format is designed to:
Key Features
Tumor Selectivity
via dual antigen recognition or affinity-tuned targeting arms
Controlled T Cell Activation
through CD3 arm engineered for optimized potency
Built-in Co-stimulation
using CD2 binding to deliver Signal 2 without systemic agonism
Mechanism of Action
1. Tumor Cell Recognition
Tumor-specific targeting arm
2. T-Cell Engagement
CD3 binding for T cell activation
3. Signal 2 Delivery
CD2 co-stimulation for enhanced response
4. Cytolyse & Immune Amplification
Targeted tumor cell destruction
Our trispecific TCEs are not just engaging — they're teaching T cells how to respond, where it matters.